Kwiminyaka yakutshanje, iteknoloji ye-nano-drug iteknoloji entsha eyaziwayo kwi-teknoloji yokulungiselela iziyobisi. Izidakamizwa ze-Nano ezifana ne-nanoparticles, ibhola okanye i-nano capsule i-nanoparticles njengenkqubo yokuthwala, kunye nokusebenza kweengqungquthela ngendlela ethile kunye emva kokuba iyeza, nayo inokwenziwa ngokuthe ngqo kwi-processing yobugcisa be-nanoparticles.
Xa kuthelekiswa neziyobisi eziqhelekileyo, i-nano-drugs ineenzuzo ezininzi ezingenakulinganiswa neziyobisi eziqhelekileyo:
Ichiza lokukhululwa kancinci, ukutshintsha isiqingatha sobomi bechiza emzimbeni, ukwandisa ixesha lesenzo sechiza;
Ilungu elithile ekujoliswe kulo lingafikelelwa emva kokuba lenziwe ichiza elikhokelwayo;
Ukunciphisa umthamo, ukunciphisa okanye ukuphelisa umphumo wecala eliyingozi phantsi kwesiseko sokuqinisekisa ukusebenza kakuhle;
I-membrane yothutho lwe-membrane itshintshiwe ukuze inyuse ukunyanzeliswa kweyeza kwi-biofilm, enenzuzo kwi-chiza yokufunxa i-transdermal kunye nokudlala ukusebenza kweziyobisi.
Ke kwezo mfuno ngoncedo lomthwali wokuhambisa amachiza kwiithagethi ezithile, ukunika indima yonyango ngokwemigaqo ye-nanodrugs, uyilo lomthwali wokuphucula ukusebenza kokujoliswa kweziyobisi kubalulekile.
Kutshanje, i-bulletin yeendaba yathi iYunivesithi yaseWales entsha yasezantsi, eOstreliya, abaphandi baphuhlisa indlela entsha, inokutshintsha imilo ye-nano carrier carrier, oku kuya kunceda ukuthuthwa kweziyobisi ezichasene nomhlaza ezikhutshwe kwi-tumor, ukuphucula umphumo we-anti. -iziyobisi zomhlaza.
Iimolekyuli zepolymer kwisisombululo zinokuqulunqwa ngokuzenzekelayo i-vesicle hollow spherical structure yepolymer, ineenzuzo zokuzinza okuqinileyo, ulwahlulo olusebenzayo lusetyenziswa ngokubanzi njengomphathi weziyobisi, kodwa, ngokuchaseneyo, njengebhaktheriya kunye nentsholongwane kwindalo iityhubhu, iintonga. , kunye nolwakhiwo lwebhayoloji olungangqukuva lunokungena lula emzimbeni. Ngenxa yokuba ii-polymer vesicles zinzima ukwenza ulwakhiwo olungekho ngqukuva, oku kuthintela ukukwazi kwepolymer ukuhambisa amayeza kwindawo yawo emzimbeni womntu ukuya kwinqanaba elithile.
Abaphandi baseOstreliya basebenzisa i-cryoelectron microscopy ukujonga utshintsho lwesakhiwo seemolekyuli zepolymer kwisisombululo. Bafumanisa ukuba ngokuguqula ubungakanani bamanzi kwi-solvent, imilo kunye nobukhulu be-polymer vesicles inokulungiswa ngokutshintsha ubungakanani bamanzi kwi-solvent.
Umbhali okhokelayo kwizifundo kunye neYunivesithi yeNew South Wales Iziko leKhemistry yepine parr sol, uthe: "Olu gqatso luthetha ukuba sinokuvelisa imilo ye-polymer vesicle inokutshintsha ngokusingqongileyo, njenge-oval okanye i-tubular, kunye nephakheji yeziyobisi kuyo." Ubungqina bokuqala bubonisa ukuba i-nano-drug carriers yendalo engaphezulu, engekho-spherical iyakwazi ukungena kwiiseli zethumba.
Uphando lupapashwe kwi-intanethi kumcimbi wamva nje wejenali yonxibelelwano lwendalo.
Ixesha lokuposa: Jul-04-2022