Isifo sezintso ezingapheliyo (CKD) izigulana zihlala zine-hyperphosphatemia, kwaye i-hyperphosphatemia yexesha elide inokukhokelela kwiingxaki ezinzulu ezifana ne-hyperparathyroidism yesibini, i-renal osteodystrophy, kunye nesifo senhliziyo. Ukulawula amanqanaba e-phosphorus yegazi yinxalenye ebalulekileyo yolawulo lwezigulane ze-CKD, kunye ne-phosphate binders ziinqobo zeyeza zonyango lwe-hyperphosphatemia. Kule minyaka yangoku,lanthanum carbonate, njengohlobo olutsha lwe-non-calcium kunye ne-non-aluminiyam i-phosphate binder, iye yangena ngokuthe ngcembe kwintsimi yombono yabantu kwaye yaqala "ukhuphiswano" kunye nezibophelelo ze-phosphate zendabuko.
"Iimfanelo" kunye "neziphene" zezibophelelo zephosphate zemveli
Izibophelelo ze-phosphate zesintu ikakhulu ziquka izibophelelo zephosphate ezine-calcium (ezifana ne-calcium carbonate kunye ne-calcium acetate) kunye nezibophelelo ze-aluminiyam ezinephosphate (ezifana ne-aluminiyam hydroxide). Zidibanisa kunye ne-phosphates ekutyeni ukwenza iikhompawundi ezinganyibilikiyo, ngaloo ndlela zinciphisa ukufunxwa kwamathumbu e-phosphorus.
Izibophelelo ze-phosphate ezine-calcium: Ixabiso eliphantsi kunye nesiphumo esicacileyo sokunciphisa i-phosphorus, kodwa ukusetyenziswa kwexesha elide kunokukhokelela kwi-hypercalcemia kunye nokwandisa umngcipheko we-vascular calcification.
Izibophelelo ze-Aluminiyam ezine-phosphorus: Impembelelo enamandla yokunciphisa i-phosphorus, kodwa ukuqokelela kwe-aluminium kunetyhefu kakhulu kwaye kunokubangela isifo sethambo esinxulumene ne-aluminium kunye ne-encephalopathy, kwaye okwangoku isetyenziswa kancinci.
I-Lanthanum carbonate: Ukunyuka kwabantu abatsha, kunye neenzuzo ezibonakalayo
ILanthanum carbonate yicarbonate ye-rare earth metal element lanthanum, enendlela eyodwa yokubopha iphosphorus. Ikhupha i-lanthanum ion kwindawo ene-acidic yendlela yokugaya kwaye yenza i-lanthanum phosphate enganyibilikiyo kunye ne-phosphate, ngaloo ndlela ikhusela ukufunxa kwe-phosphorus.
Intshayelelo emfutshane ye-lanthanum carbonate
| Igama lemveliso | ILanthanum carbonate |
| Ifomula | I-La2(CO3)3.xH2O |
| Inombolo yeCAS. | 6487-39-4 |
| Ubunzima beMolekyuli | 457.85 (anhy) |
| Ukuxinana | 2.6 g/cm3 |
| Indawo yokunyibilika | N / A |
| Imbonakalo | Umgubo wekristale omhlophe |
| Ukunyibilika | Inyibilika emanzini, ngokuphakathi inyibilika kwii-asidi zeminerali ezomeleleyo |
| Uzinzo | I-hygroscopic ngokulula |
Xa kuthelekiswa nezibophelelo ze-phosphorus zemveli, i-lanthanum carbonate inezi nzuzo zilandelayo:
Akukho calcium kunye ne-aluminium, ukhuseleko oluphezulu: Ugwema umngcipheko we-hypercalcemia kunye ne-aluminium poisoning, ngakumbi kwizigulane ezinonyango olude kunye nomngcipheko wokubalwa kwe-vascular calcification.
Ikhono lokubopha i-phosphorus elomeleleyo, isiphumo esibalulekileyo sokunciphisa i-phosphorus: I-Lanthanum carbonate inokubopha ngokufanelekileyo i-phosphorus kuluhlu olubanzi lwe-pH, kwaye amandla ayo okubopha anamandla kunezibophelelo ze-phosphorus zendabuko.
Ukuncipha kokuchaneka kwesisu, ukuthobela isigulana kakuhle: ILanthanum carbonate incasa kakuhle, kulula ukuyithatha, ayinakucaphuka kancinane emathunjini, kwaye izigulane zinokubambelela kunyango lwexesha elide.
Ubungqina bophando lweklinikhi: I-Lanthanum carbonate isebenza kakuhle
Izifundo ezininzi zeklinikhi ziqinisekisile ukusebenza kunye nokhuseleko lwe-lanthanum carbonate kwizigulane ze-CKD. Ucwaningo luye lwabonisa ukuba i-lanthanum carbonate ayikho ngaphantsi okanye ingaphezulu kunezibophelelo ze-phosphate zendabuko ekunciphiseni amanqanaba e-phosphorus yegazi, kwaye inokulawula ngokufanelekileyo amanqanaba e-iPTH kunye nokuphucula izikhombisi ze-bone metabolism. Ukongezelela, ukhuseleko lonyango lwexesha elide kunye ne-lanthanum carbonate lulungile, kwaye akukho qoqo olucacileyo lwe-lanthanum kunye neempendulo ezinobuthi zifunyenwe.
Unyango lomntu ngamnye: Khetha esona sicwangciso sisigulana
Nangona i-lanthanum carbonate ineenzuzo ezininzi, oko akuthethi ukuba inokutshintsha ngokupheleleyo izibophelelo ze-phosphate zendabuko. Ichiza ngalinye linezibonakaliso zalo kunye nokuchasana, kwaye isicwangciso sonyango kufuneka sibe ngumntu ngamnye ngokwemeko ethile yesigulane.
ILanthanum carbonate ifaneleka ngakumbi kwezi zigulana zilandelayo:
Izigulane ezine-hypercalcemia okanye umngcipheko we-hypercalcemia
Izigulane ezine-vascular calcification okanye ingozi ye-vascular calcification
Izigulane ezinonyamezelo olulambathayo okanye ukungasebenzi kakuhle kwezibophelelo zephosphate zesintu
Izibophelelo zephosphate zesintu zisenokusetyenziswa kwezi zigulana zilandelayo:
Izigulane ezineemeko zoqoqosho ezilinganiselweyo
Izigulana ezingadibaniyo okanye ezinganyamezeliyo i-lanthanum carbonate
Ukukhangela kwixesha elizayo: ILanthanum carbonate inekamva eliqaqambileyo
Ngokunzulu kophando lweklinikhi kunye nokuqokelela amava ekliniki, imeko ye-lanthanum carbonate kunyango lwe-hyperphosphatemia kwizigulane ze-CKD iya kuqhubeka nokuphucula. Kwixesha elizayo, i-lanthanum carbonate kulindeleke ukuba ibe yi-phosphate binder yomgca wokuqala, izise iindaba ezilungileyo kwizigulane ezininzi ze-CKD.
Ixesha lokuposa: Mar-25-2025